The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Д¬ompeting interests: The authors have declared that no competing interests exist. IS and ST acknowledge fellowship support from UGC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ДЇunding: Funds for this study were obtained from the University Grants Commission (UGC), India via grant number F.31-287/2005(SR) and Department of Science and Technology (DST-FIST) and UGC-SAP (UGC special assistance program) to the Department of Biochemistry. Received: OctoAccepted: JanuPublished: February 15, 2012Д¬opyright: В© 2012 Srividya et al. Lustig, Tulane University Health Sciences Center, United States of America We further show that Rtt103 associates with sites of DNA breaks and hence is likely to play a direct role in response to DNA damage.Д¬itation: Srividya I, Tirupataiah S, Mishra K (2012) Yeast Transcription Termination Factor Rtt103 Functions in DNA Damage Response. We show that rtt103О” are sensitive to multiple forms of genome insults and that RTT103 is essential for recovery from DNA double strand breaks in the chromosome. One of the suppressors identified was RTT103, which encodes a protein implicated in transcription termination. To identify components in molecular networks involved in the multiple functions of Yku70/80 complex, we performed a genetic screen for suppressors of yku70 deletion. These proteins protect telomeres from recombination events, nuclease attacks, support the formation of heterochromatin at telomeres and anchor telomeres to the nuclear periphery. Yku70/80 proteins are associated with telomeres and are important for maintaining the integrity of telomeres. YKu70/YKu80 is a heterodimer that is essential for repair of DNA double strand breaks through non-homologous end joining pathway in the yeast Saccharomyces cerevisiae.

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